The D1 dopamine receptor is predominantly expressed on the STIATONIGRAL NEURONS, while the D2 receptors are primarily found on the STRAITOPALLIDAL NEURONS.
Evidence suggests that in the striatum the D1 and D2 receptors have, respectively, an EXCITATORY ( STRIATONIGRAL) and INHIBITORY action( STRIATOPALIDO)
Activation of the D1 receptors appears to be important in mediating DYSTONIC MOVEMENTS,whereas activation of the D2 receptors may result in CHOREA.
The dopaminergic deafferentation produces an imbalance in the stratal activity, with HYPOACTIVITY OF THE STRAITONIGRAL PATHWAY, and HYPERACTIVITY OF THE STRIATOPALLIDAL PATHWAYS.
The final effect of Dopamine deficiency is poverty or slowness of movements( HYPOKINESIA)
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